Cisplatin anticancer mechanism

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August undefined, 2024

WebJun 26, 2024 · The cytotoxic action of cisplatin is conditioned by the covalent binding of this molecule to N-7 purine atoms on high affinity DNA, which leads to the cross-link of DNA strands and inhibition of... WebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the drugs was measured by clonogenic assay. Chromatin condensation was observed by co-staining with fluorescent dyes, Hoechst 33342 and propidium iodide. Apoptotic sub-G1 was …

Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin

WebJun 20, 2024 · Cisplatin [cis-diamminedichloroplatinum(II) (cis-DDP)] is one of the most successful anticancer agents employed today and is effective against a wide range of … WebCisplatin, a class of platinum-containing anticancer drugs for the treatment of solid tumors, is a substrate of OCT2 and MATE1/MATE2-K. OCT2 is expressed in the basolateral … small worlds david shute

Synthesis, characterization and anticancer mechanism studies of ...

WebSep 5, 2011 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions … WebJul 1, 2024 · Cisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine … National Center for Biotechnology Information www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov hilary hahn bach gigue

Cisplatin: The first metal based anticancer drug

WebCisplatin is administered to cancer patients intravenously as a sterile saline solution (that is, containing salt—specifically, sodium chloride). Once cisplatin is in the bloodstream, it … WebCisplatin enters the cell either passively or through a transporter, where two water molecules replace the chloride groups. As an electrophile, cisplatin is attracted to the nitrogen on purine bases in the DNA, where it forms inter or intra-strand crosslinks, interrupting DNA repair and replication processes. small worlds closedWebMar 15, 2011 · Numerous mechanisms of cisplatin resistance were described including changes in cellular uptake, drug efflux, increased detoxification, inhibition of apoptosis and increased DNA repair. To minimize cisplatin resistance, combinatorial therapies were developed and have proven more effective to defeat cancers. small worlds clean

"WebNov 2, 2024 · Among other cancers, cisplatin is used as a first-line treatment for: leukemia lymphoma breast cancer testicular cancer ovarian cancer head and neck cancer cervical … " - Cisplatin anticancer mechanism

Cisplatin anticancer mechanism

Cisplatin: mode of cytotoxic action and …

WebTwo major issues which hamper the use of the anticancer drug cisplatin are the development of cancer cell resistance and its nephrotoxicity. One possible mechanism by which resistance is reported to develop is a reduction in … WebCisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced cancer that cannot be treated with other therapies, …

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WebApr 29, 2024 · In order to overcome cisplatin-resistance, seven cyclometalated ruthenium ( II) complexes were synthesized with a varying degree of fluorine substitution, for use as anticancer agents. A cytotoxicity assay testified that the complexes possessed a more cytotoxic effect than cisplatin towards the cisplatin-resistant cell line A549R. WebDiverse molecular mechanisms underlying cisplatin resistance including decreased cellular uptake, increased cellular efflux, enhanced cellular inactivation, and increased cellular tolerance to DNA damage have been described for different cancer types.

Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need alternative therapy options. Researchers... WebCisplatin (DDP) is a common therapeutic option for non‐small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... 36 The main anticancer molecular mechanisms of DDP include: (1) induction of oxidative stress characterized by reactive oxygen species and lipid peroxidation; (2) ...

WebTherapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new … WebCisplatin (DDP) has been a significant tumor chemotherapy against various solid malignant tumors, including lung adenocarcinoma, since it was approved by the Food and Drug Association in 1978.7Platinum chemotherapy drugs, represented by DDP, are antitumor agents.

WebApr 29, 2024 · The drug-resistance of cancer cells has become a major obstacle to the development of clinical drugs for chemotherapy. In order to overcome cisplatin …

WebA deep knowledge of the biochemical mechanisms, which are triggered in the tumor cell … small worlds how to craft pacifierWebApr 12, 2012 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions followed by the activation of the DNA damage response … hilary hahn cso dateWebNov 24, 2024 · 1.1. Lung Cancer. Among all forms of cancer, lung cancer is the leading cause of mortality worldwide [1, 2]. Despite advances in development of new treatment modalities, the overall 5-year survival rate has only slightly increased over 2.5 decades, remaining at approximately 16% [4, 5].Early diagnostic procedures and hits, and effective … hilary hahn csoWebCisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA … hilary hahn concertgebouwWebCisplatin biochemical mechanism of action: from cytotoxicity to induction of cell death through interconnections between apoptotic and necrotic pathways. Although cisplatin, cis-diamminedichloroplatinum(II), has been successfully used in the chemotherapy of cancer for more than 25 years, its biochemical mechanism of action is still unclear. hilary hahn - eclipse 2022Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need … small worlds ivWeb2 days ago · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid … small worlds designer